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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Superbinder based phosphoproteomic landscape revealed PRKCD_pY313 mediates the activation of Src and p38 MAPK to promote TNBC progression

Fig. 7

PRKCD related kinase activity in TNBC cell lines with different PRKCD_pY313 levels and changes after dasatinib treatment. (A) PRKCD-related kinases and their phosphorylation levels in MDA-MB-231 cells with different levels of PRKCD_pY313. (B) PRKCD-related kinases and their phosphorylation levels in MDA-MB-231 cells with PRKCD_pY313 knockdown and knockout. (C) PRKCD-related kinases and their phosphorylation levels in BT549 cells with different levels of PRKCD_pY313. (D) Kinases activity in BT549 cells with different PRKCD_pY313 level among dasatinib treatment. (E) Kinases activity in MDA-MB-231 cells with different PRKCD_pY313 level among dasatinib treatment. (F) The MTT assay of MDA-MB-231 cells with different PRKCD_pY313 level among 0.05 μM dasatinib and/or 20 μM Adezmapimod treatment. (G) The MTT assay of BT549 cells with different PRKCD_pY313 level among 0.05 μM dasatinib and/or 20 μM Adezmapimod treatment. All the results were presented from 3 independent experiments. Mean ± SD, n = 3 per group, * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001

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Cell Communication and Signaling

ISSN: 1478-811X