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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Superbinder based phosphoproteomic landscape revealed PRKCD_pY313 mediates the activation of Src and p38 MAPK to promote TNBC progression

Fig. 6

PRKCD_pY313 promoted the growth of tumor in the xenograft models. (A) Tumor volume of BT549 cells stably overexpressing PRKCD_pY313 or PRKCD_Y313F which was transplanted into BALB/c nude mice. (B) The tumor weights of BT549 cells stably overexpressing PRKCD_pY313 or PRKCD_Y313F which was transplanted into BALB/c nude mice. (C) The tumor growth curve of BT549 cells stably overexpressing PRKCD_pY313 or PRKCD_Y313F which was transplanted into BALB/c nude mice. (D) Tumor volume of MDA-MB-231 cells stably overexpressing PRKCD_pY313 or PRKCD_Y313F which was transplanted into BALB/c nude mice. (E) The tumor weights of MDA-MB-231 cells stably overexpressing PRKCD_pY313 or PRKCD_Y313F which was transplanted into BALB/c nude mice. (F) The tumor growth curve of MDA-MB-231 cells stably overexpressing PRKCD_pY313 or PRKCD_Y313F which was transplanted into BALB/c nude mice. Scale Bars = 25um. (G) IHC staining of PRKCD, Ki-67, Bad, Bcl-xl, and Cleaved caspase 3 in xenograft tumor samples transplanted with BT549 cells stably overexpressing PRKCD_pY313 or PRKCD_Y313F. (H) IHC staining of Vimentin and ZO1 in xenograft tumor transplanted with BT549 cells stably overexpressing PRKCD_pY313 or PRKCD_Y313F. IHC, immunohistochemistry. Scale Bars = 25um. Mean ± SD, n = 3 per group, * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001

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Cell Communication and Signaling

ISSN: 1478-811X