Fig. 3

Significant phosphorylated serine/threonine peptides and personalized kinase map of patients with TNBC. A The significant pS/pT peptides in 38 pairs of breast cancer specimens and paired adjacent normal specimens, ranked by log₂FC value. B The personalized kinase activity map of patient with triple-negative breast cancer based on the pY-pS/pT associated genes. Each protein frame is divided into four small squares, each of which represents one pY, pS or pT site. The color represents the log₁₀(Ca/N) value, red represents the upregulation of this site, and the darker the color, the higher the upregulation ratio. Blue indicates downregulation, darker color indicates higher downregulation, and gray indicates no such site. The color of the border of each protein bar represents the sum of the log₁₀(Ca/N) values of all sites of the protein. The thickness of the lines between the proteins indicates a test score ranging from 1 to 10, and the color of the lines ranging from gray to red indicates a test score ranging from 0 to 1. TNBC, triple-negative breast cancer; KEGG, Kyoto Encyclopedia of Genes and Genomes; FC, fold change; Ca/N, ratio of expression levels in breast cancer tumors to that in normal breast tissue