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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Superbinder based phosphoproteomic landscape revealed PRKCD_pY313 mediates the activation of Src and p38 MAPK to promote TNBC progression

Fig. 2

Significant phosphorylated tyrosine peptides in breast cancer tissues and functional analysis. A The significant pY peptides in 47 pairs of breast cancer specimens and paired adjacent normal specimens from mass spectrometry analysis, ranked by log2FC value. B Barplot of top 10 KEGG pathways of significant pY peptides related genes. C Intersection protein-protein interaction networks of PRKCD related genes among pY, pS or pT significant proteins in the mass spectrometry analysis. The triangle represents the substrates of PRKCD; the diamond represents the kinases of PRKCD; the circle represents the kinases and substrates of PRKCD. D The phosphorylated level analysis of PRKCD_pY313 and some of its related kinases (MAPK3_pY215, MAPK7_pY221, MAPK12_pY185, MAPK13_pY182, MAPK14_pY182) based on mass spectrometry data. pY, phosphorylated tyrosine; FC, fold change; KEGG, Kyoto Encyclopedia of Genes and Genomes. * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001

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Cell Communication and Signaling

ISSN: 1478-811X