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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Large-scale phosphoproteomics reveals activation of the MAPK/GADD45β/P38 axis and cell cycle inhibition in response to BMP9 and BMP10 stimulation in endothelial cells

Fig. 2

Analysis of phosphoproteomic changes in response to BMP9 and BMP10 in HUVECs. A and B Volcano plots representing the log2 fold change in the abundance of phosphopeptides plotted against the –log10 adj. P.value, showing differentially phosphorylated sites (DPS) which are down-phosphorylated (blue) or up-phosphorylated (red) in response to BMP9 (A) or BMP10 (B) stimulation. DPSs from the canonical ALK1/SMAD1 signaling pathway as well as those which will be further studied in the work are annotated. C SMAD1 linear structure showing the MH1 (MAD homology domain 1) and MH2 domain, along with the C-terminal SSXS motif sites highlighted in panels A and B. D Scatter plot comparing log2 fold change values of DPS regulated by BMP9 and BMP10. Pearson’s correlation (r) is reported

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Cell Communication and Signaling

ISSN: 1478-811X