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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: K-Ras(V12) differentially affects the three Akt isoforms in lung and pancreatic carcinoma cells and upregulates E-cadherin and NCAM via Akt3

Fig. 8

Akt isoforms differentially affect the expression of transcription factors. A The mRNA content of CDH1 is given in H23 Akt-kd clones. Relative expression was assessed in relation to RPLP0 and to the expression in the cell clone transduced with a scrambled shRNA [Scr] set to 1. Each sample was analyzed in duplicate (n = 4). B, C The mRNA content of  ZEB1, SNAI1, SNAI2 was determined by qRT-PCR analysis in (B) H23 Akt-kd clones and (C) PANC-1/EGFP-K-Ras(V12) Akt-kd clones. Relative expression was assessed in relation to RPLP0 and to the expression in the cell clone transduced with a scrambled shRNA [Scr] set to 1. Each sample was analyzed in duplicate (n = 3–5). Mean ± SD (one sample t-test, ** p ≤ 0.01; * p ≤ 0.05) is shown

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Cell Communication and Signaling

ISSN: 1478-811X