Table 2 Small molecule compounds that regulate or target AXIN1
From: The scaffold protein AXIN1: gene ontology, signal network, and physiological function
Agents | Effect | Mechanism | References |
|---|---|---|---|
XAV939 | Stabilization of AXIN1 | Inhibiting TNKS1/2 | [62] |
IWR-2/3 | Stabilization of AXIN1 | Perhaps by inhibiting TNKS1/2 | [183] |
SKL2001 | Active WNT/β-catenin | Disrupts the AXIN1/β-catenin interaction | [184] |
HLY78 | Active WNT/β-catenin | Potentiates the AXIN1/LRP6 interaction | [185] |
SEN461 | Stabilization of AXIN1 | Unknown | [186] |
Lithium ion | Depletion of AXIN1 | Unknown | [187] |
FK866 | Stabilization of AXIN1 | Unknown | [182] |
Ophiopogonin B | Stabilization of AXIN1 | Unknown | [188] |