Fig. 6
From: The scaffold protein AXIN1: gene ontology, signal network, and physiological function
AXIN1 regulatory control on AMPK and mTOR signaling pathways. In heightened energy states, mTORC1 activation unfolds at the lysosomal membrane via the engagement of the v-ATPase-Ragulator-RAGs complex. Concomitantly, an abundance of ATP exerts inhibitory effects, delicately modulating the assembly of the AXIN1-LKB1-AMPK complex and subsequently attenuating AMPK signaling. In contrast, under conditions of energy scarcity, AXIN1 undergoes recruitment to the lysosomal membrane through the v-ATPase-Ragulator complex. This orchestrated move directly quells mTORC1 signaling. Concurrently, elevated AMP levels stimulate the assembly of the AXIN1-LKB1-AMPK complex, thereby igniting AMPK signaling