Fig. 5
From: The scaffold protein AXIN1: gene ontology, signal network, and physiological function
AXIN1 regulatory control on Hippo and TGF-β Signaling. A Within the Hippo signaling cascade, the destruction complex undergoes phosphorylation catalyzed by LATS1/2, initiating a cascading series of post-translational modifications culminating in the ultimate degradation of YAP/TAZ. This process is facilitated through the UPS pathway. B In the context of TGF-β signaling, AXIN1 emerges as a pivotal actor, engaging directly with SMAD3/5/7. This interaction serves as the impetus for the degradation of SMAD proteins via the UPS pathway