Fig. 4
From: The scaffold protein AXIN1: gene ontology, signal network, and physiological function
AXIN1 regulatory control on WNT/β-catenin Signaling. During WNT inactivity (WNT OFF), the homeostasis of β-catenin relies on the intricacies of the destruction complex, governing its proteasomal degradation through UPS pathway. Multiple factors, including FRAT1, PP1, PP2A, RIF1, SIRT4, and ZBED3, exert their influence on AXIN1 to inhibit the function of the destruction complex. Additionally, C9orf140, DAB2, TFEB, and WDR26 act on AXIN1 to facilitate the functioning of the destruction complex. When the WNT pathway is activated (WNT ON), AXIN1 is recruited to the WNTs-LRP5/6-FZDs-DVL complex, thereby relieving the suppression of the destruction complex on β-catenin. PAR2 serves to inhibit this process by acting on AXIN1, while γ-Pcdh-C3, SENP2, and SMURF1 also contribute to the inhibition of this process through interactions with AXIN1