Skip to main content
Fig. 6 | Cell Communication and Signaling

Fig. 6

From: The pathogenic role of succinate-SUCNR1: a critical function that induces renal fibrosis via M2 macrophage

Fig. 6

CTGF neutralizing antibody inhibited the stimulation of fibroblasts by macrophage-conditioned medium. A CTGF antibody prevented the proliferative effects of CM on NRK-49F, indicated by the results of the CCK8 assay. ***P < 0.001, versus control group, n = 6 in CCK8, biologically repeated 3 times. B Also, the CTGF antibody suppressed the activation effects of CM on NRK-49F, as indicated by the results of the protein quantitative analysis of fibronectin and α-SMA. ***P < 0.001, versus control group, &&&P < 0.001, versus the succinate group, n = 3, biologically repeated 3 times

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X