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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Cigarette tar accelerates atherosclerosis progression via RIPK3-dependent necroptosis mediated by endoplasmic reticulum stress in vascular smooth muscle cells

Fig. 4

RIPK3 deletion ameliorated atherosclerosis progression caused by cigarette tar. A Representative images and quantification of Oil Red O staining in descending aorta. Scale bar: 2 mm. n = 8. B Representative images and quantification of Oil Red O in aortic roots. Scale bar: 200 μm. n = 5. C HE staining and quantification of plaque area and necrotic core area in aortic roots. Scale bar: 200 μm. n = 8. D Masson staining and quantification of collagen content and the percent of fibrous cap area in aortic roots. Scale bar: 200 μm. n = 8. E α-SMA (VSMCs) immunofluorescence staining and the percentage of it in the total lesion area. The position between the double dashed lines indicated the fibrous cap. Scale bar: 100 μm. n = 8. F-G Western blot analysis necroptosis protein levels. n = 6. Data were expressed as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001

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Cell Communication and Signaling

ISSN: 1478-811X