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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Dopamine modification of glycolytic enzymes impairs glycolysis: possible implications for Parkinson’s disease

Fig. 5

Metabolic dysfunction caused by DA-induced mitochondrial damage. A, B Measurement of the extracellular acidification rate (ECAR) and its indicators in MN9D cells treated with indicated concentrations of DA for 12 h. C, D Measurement of the oxygen consumption rate (OCR) and its indicators in MN9D cells treated with indicated concentrations of DA for 12 h. E Volcano plot of the different metabolites in MN9D cells treated with 400 μM DA. Red and blue dots represent the upregulated and downregulated metabolites respectively. F KEGG pathway enrichment analysis of DA-targeted metabolites. Top 10 pathways are shown. G Schematic representation of the glycolysis pathway. H-J Quantification of glycolysis intermediates after 400 μM DA treatment for 12 h. All error bars represent the mean ± s.d. n.s., not significant; *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001

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Cell Communication and Signaling

ISSN: 1478-811X