Fig. 9From: PRDX6-iPLA2 aggravates neuroinflammation after ischemic stroke via regulating astrocytes-induced M1 microgliaMechanisms of a novel role for PRDX6 and iPLA2 in regulating astrocyte-induced ROS production and ROS-induced microglia/infiltrated macrophage polarization by activating the NOX2 and Drp1‑mitochondrial fission pathways. Further, PRDX6-iPLA2 activity is regulated by ERK and P38 via phosphorylation of PRDX6 at Thr177 in astrocytesBack to article page