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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: PRDX6-iPLA2 aggravates neuroinflammation after ischemic stroke via regulating astrocytes-induced M1 microglia

Fig. 8

MAPK activity mediates phosphorylation of PRDX6 and its translocation to the cell membrane in astrocytes after OGD/R. a Western blot analysis of ERK, p-ERK, P38 and p-P38 in CTX-TNA2 cells. b iPLA2 activity in CTX-TNA2 cells. C Molecular docking of ERK with PRDX6, P38 with PRDX6. d, f Western blot analysis of PRDX6, p-PRDX6, membranous PRDX6. e Immunoprecipitation and immunoblot analyses of ERK-PRDX6 in CTX-TNA2 cells. g Immunoprecipitation and immunoblot analyses of P38-PRDX6 in CTX-TNA2 cells. h Immunoprecipitation and immunoblot analyses of ERK-PRDX6 or P38-PRDX6 in HEK293T cells. Values are mean ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. n = 6 per group

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Cell Communication and Signaling

ISSN: 1478-811X