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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: PRDX6-iPLA2 aggravates neuroinflammation after ischemic stroke via regulating astrocytes-induced M1 microglia

Fig. 3

Inhibition of PRDX6-iPLA2 influences astrocyte and microglia activation in the ischemic penumbra. a Immunocytochemistry of Iba-1 staining for microglia. Immunocytochemistry of GFAP staining for astrocytes. PRDX6 expression and location was measured by immunohistochemistry in rats after treatment with MJ33. Cell nuclei were stained with DAPI (× 400). b Histogram reveals the number of the activated GFAP + astrocytes. c Histogram shows PRDX6 + astrocytes. d Histogram reveals the amoebodilike microglia. e Immunocytochemistry of Iba-1 staining for microglia. CD16 and CD206 expression were detected by immunohistochemistry in microglia after treatment with MJ33. Cell nuclei were stained with DAPI (× 400). f Histogram reveals the number of CD16 + microglia and CD206 + microglia. g Quantification of IL-1α, IL-1β, IL-6, and TNF-α in rats by ELISA. Values are mean ± SEM, * p  < 0.05, ** p  < 0.01, *** p  < 0.001, **** p  < 0.0001. n  = 6 per group

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Cell Communication and Signaling

ISSN: 1478-811X