Fig. 4From: Dexamethasone exposure during pregnancy triggers metabolic syndrome in offspring via epigenetic alteration of IGF1 Effects of prenatal dexamethasone exposure (PDE) on postnatal liver development and the levels of corticosterone (CORT) and insulin-like growth factor 1(IGF1) at postnatal week (PW) 6 and 12. A The mRNA expression of liver development-related genes at PW6 (n = 8); (B) Serum CORT at PW6 (n = 8); (C) Serum IGF1 level at PW6 (n = 8); (D) The mRNA expression of liver IGF1 signaling pathway expression at PW6 (n = 8); (E) Serum CORT with or without unpredictable chronic stress (UCS) at PW12 (n = 8); (F) Serum IGF1 level with or without UCS at PW12 (n = 8); (G) The mRNA expression of liver IGF1 signaling pathway expression with or without UCS at PW12 (n = 8); (H) The mRNA expression of liver development-related genes with or without UCS at PW12 (n = 8). Mean ± S.E.M. * P < 0.05, ** P < 0.01 vs. the control group. NS, no significance; PDE(L), prenatal dexamethasone exposure at a low dose (0.2 mg/kg∙d)Back to article page