Fig. 1

IRE1α signature score is highly correlated with the feature of tumor-infiltrating lymphocytes in melanoma. A Correlation analysis of 38-hub genes representative of the IRE1α signature with tumor-infiltrating lymphocytes score in TCGA SKCM database. B The mRNA expression of Th1-, cytotoxic mechanisms-, chemokines-, T cell, and MHC class I and II genes based on the groups defined relative to IRE1α activity (High or Low) in TCGA SKCM database. C Correlation analysis of XBP1 with PTPRC, CD8A, GZMB and IFN-γ expression in TCGA SKCM database. D Correlation analysis of DNAJB9 and EDEM1 with PTPRC, CD8A and IFN-γ expression in TCGA SKCM database. E Immunohistochemical staining and correlation analysis of XBP1, CD8α and IFN-γ in a cohort of 31 melanoma tissues. Pt.1, Patient 1; Pt.2, Patient 2. Scale bar = 50 μm. F The overall survival of melanoma patients based on the groups defined relative to IRE1α activity (High or Low) in TCGA SKCM database. G The overall survival of melanoma patients with high TIL score (hot tumor) or low TIL score (cold tumor) based on the groups defined relative to IRE1α activity (High or Low) in TCGA SKCM database. r value was calculated by Spearman correlation. p value was calculated by two tailed Student’s t-test