Fig. 2
From: Emerging roles of the Protein Phosphatase 1 (PP1) in the context of viral infections
PP1 is recruited by some viruses to rescue host translation activity. dsRNA sensing and viral protein accumulation in ER activates the PKR and PERK, respectively, culminating in eIF2α phosphorylation at Ser51 and host cell translation shut-off. This process is reversed by the PP1:GADD34 holoenzyme. HSV-1 γ34.5, ASFV DP71L, and TGEV protein 7 are viral orthologues of GADD34 and interact with PP1 to promote eIF2α dephosphorylation and protein synthesis rescue. Some viruses – DENV, HCV, NDV, HPV, PRV, and IBV –modulate the activity of host-cell PP1:GADD34. Figure created with BioRender.com