Fig. 1
From: Emerging roles of the Protein Phosphatase 1 (PP1) in the context of viral infections
Schematic representation of the interplay between PP1 and different viruses. A HIV-1 Tat recruits PP1 for nuclear translocation, thereby promoting the P-TEFb dephosphorylation at the CDK9 Thr186 and enhanced transcription elongation of the viral genome. B EBOV and MARV VP30 are substrates of PP1 and their dephosphorylation shifts the RNA polymerase complex activity towards viral transcription. Since VP30 proteins are devoid of PP1-binding motifs, the PP1:VP30 interaction appears to be mediated by an unknown RIPPO. C In CREB-induced transcription, PP1 is recruited by HDAC1 to promote CREB dephosphorylation and inhibition. HBx binds to the CREB and interacts with the PP1:HDAC1 complex, to prevent CREB dephosphorylation. Thus, HBx promotes CREB-mediated HBV transcription. Also, PP1 dephosphorylates HBV Cp and it is encapsulated together with HBV pgRNA. D HSV-1 pUL21 and VZV pORF38 recruit PP1 to induce dephosphorylation of other viral or host proteins. During HSV-1 infection, the PP1:pUL21 complex dephosphorylates CERT, which contributes to host lipid traffic between the endoplasmic reticulum and the Golgi complex. For all figures, dash lines represent PP1 interactions that are not fully understood. Figure created with BioRender.com