Table 2 Investigations involving Types of AQPs with the respective inhibitory molecules for specific Cancer cell lines

AQP1

Ion channel Blocker

H2T9

Cell Migration

[60]

Carbonic Anhydrase inhibitor-Acetazolamide

Glioma cell line

Invasion and angiogenesis

[81, 87]

AQB050

primary malignant mesothelioma cells

Reduction in cell growth

[89]

cyclophosphamide, topiramate and anaesthetic drugs

AQP1 inhibitors

[181]

Rg3

PC-3 M prostate cancer cell line

Inhibited p38 MAPK pathway

[92]

Tetraethyl ammonium

J82 human bladder cancer cells

Blocks AQP1

[95]

microRNA-320 AQP1 siRNA

LTEP-A2 and LLC lung cancer cell lines; HMEC-1 human endothelial cells

Downregulating matrix metalloprotease; Lack of F-actin polarisation

[68, 79, 80]

shRNA

U2OS and MG63 osteosarcoma

Decrease in proliferation, Reduced TGF-B signalling

[31]

AQP2

Oestrogen receptor blocker ICI182780

Ishikawa cells in human Endometrial cancer

Reduced invasion, proliferation and migration

[33]

AQP3

RNAi

XWLC-05 Lung cancer cells Pancreatic BXPC3, HPAFII MDA-IBC3 breast cancer cell lines

Reduced proliferation and invasion

Reduced cell growth and proliferation

Diminished tumour migration

[122, 124, 133]

Auphen and dbcAMP

DU-135 & PC-3 prostate cancer cells

HCC cells

Reduced matrixmetalloprotease3

Reduced HCC development

[129]

Curcumin

CaOV3 ovarian cell line

Reduced cell migration

[132]

AQP4

siRNA mediated knockdown;

Monoclonal AQP4-IgG conjugated with toxin

Glioblastoma cells

Cellular apoptosis and Selective cytotoxicity respectively

[11, 142, 143]

AQP5

RNAi

MCF7 Breast cancer cell line

Tounge SCC cell line

LAMA84 CML cells

Reduced cell migration & proliferation

Decreased cell migration

Reduced cell proliferation

[45, 48, 156]

Short hairpin RNA

Lung adenocarcinoma SPCA1 cell line

Reduced cell migration

[159]

P38 MAPK inhibitor

HT-29 cells colon cancer

Reduced p38 phosphorylation

[160]

Cairicoside E

Colon cancer cells

Decreased EMT

[163]

Acetazolamide

Gastric cancer cells

Reduced proliferation and invasiveness

[51, 52]

HgCl₂

MKN45 gastric cancer cells

Reduced number of differentiated cells

[164]

miR-1226–3p, miR-19a-3p, and miR-19b-3p

Breast cancer cells

Reduced cell motility

[167]

Epigallectocatechin gallate

SKOV3 ovarian cancer cells

Promoted apoptosis and inhibited cell proliferation

[175]