Fig. 2
From: Pyroptosis: a double-edged sword in lung cancer and other respiratory diseases
Pyroptotic pathway. GSDM superfamily members have six members: Gasdermin A (GSDMA), Gasdermin B (GSDMB), Gasdermin C (GSDMC), Gasdermin D (GSDMD), Gasdermin E (GSDME, DFNA5), and DFNB59. Gasdermins except for DFNB59 have similar architecture of two domains: an N-terminal and a C-terminal. N-terminal domains have pore-forming activities and activate pyroptosis. Pyroptosis has been reported to be involved in many pulmonary diseases. (Solid line: promoting effect, dotted line: inhibiting effect)