Skip to main content
Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Non-canonical non-genomic morphogen signaling in anucleate platelets: a critical determinant of prothrombotic function in circulation

Fig. 5

Scheme depicting the role of Notch signaling in stimulated platelets. There is juxtacrine interaction between DLL-4 and Notch1 expressed on surfaces of agonist-stimulated platelets that remain in close proximity within platelet aggregates. This leads to Notch-mediated non-canonical PI3K-AKT signaling in the partner platelet potentiating thrombin-induced platelet activation responses and thrombus formation, which can be blocked by anti-DLL-4 antibody or inhibitors of γ-secretase (DAPT or DBZ)

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X