Fig. 4
From: NPFs-mediated actin cytoskeleton: a new viewpoint on autophagy regulation
The involvement of NPFs and actin cytoskeleton in different events of autophagy. NPFs mainly depend on the assembly of Arp2/3-mediated actin cytoskeleton to participate in the generation of autophagosomes after the formation of omegasome, the transport of ATG9 vesicles and autophagosomes, the fusion of autophagosomes and lysosomes, and the ALR process. LC3 and phosphoinositides on autophagosome or autolysosome membranes may be the sites where NPFs anchor, and this binding may be a necessary process for NPFs to participate in autophagy