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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Connexin32 gap junction channels deliver miR155-3p to mediate pyroptosis in renal ischemia-reperfusion injury

Fig. 7

Correlation between Cx32 and its GJ and TECs' pyroptosis signaling pathway during renal I/R. In renal IR-induced AKI, damaged renal tubular cells transmit miR155-3p to neighboring cells through Cx32-GJ, which leads to NLRP3-mediated renal tubular epithelial pyroptosis and aggravates renal injury. When the function of Cx32- GJ is inhibited, the transmission of miR155-3p between cells is weakened, pyroptosis is inhibited, and renal injury is effectively alleviated. RIR: renal ischemia reperfusion; ASC: apoptosis-associated speck-like protein containing a caspase recruitment domain; Casp1: caspase 1

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Cell Communication and Signaling

ISSN: 1478-811X