Table 1 Sirtuins in renal component cells
From: Sirtuins in kidney diseases: potential mechanism and therapeutic targets
Cell types | Sirtuins | Mechanisms |
|---|---|---|
Podocytes | Sirt1, Sirt3, Sirt4, Sirt6, Sirt7 | Inflammation, autophagy, lipid metabolism, mitochondrial dysfunction, actin cytoskeleton, apoptosis, oxidative stress, DNA damage, insulin resistance |
Endothelial cells | Sirt1, Sirt3, Sirt6 | Endothelial disfunction, inflammation, apoptosis, oxidative stress, fibrosis, aging, metabolic reprogramming |
Mesangial cells | Sirt1, Sirt6 | Fibrosis, inflammation, oxidative stress |
Renal tubular epithelial cells | Sirt1, Sirt2, Sirt3, Sirt4, Sirt5, Sirt6, Sirt7 | Inflammation, fibrosis, apoptosis, oxidative stress, autophagy, mitochondrial dysfunction, mitophagy, G2/M phase arrest |
Macrophages | Sirt1, Sirt3, Sirt6 | Inflammation, macrophage infiltration and activation |