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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Simulation of gap junction formation reveals critical role of Cys disulfide redox state in connexin hemichannel docking

Fig. 5

Closed and open disulfides can be related to open (ON) and closed (OFF) channel functions. Dynamics of channel diameter in the whole channel and specifically in the extracellular region (left) and visualization of the water accessible channel as determined by the HOLE software after 50 ns MD simulation (right) in the Cx43 HC structure [67] (A), in the HC-HC model constructed from the Cx43 HC structure [67] (B) and in the Cx43 GJC structure [67] (C). Water accessible channel is visualized as blue shape, lipids are shown in olive, Cx residues are colored according to atom type. Lipids and connexins are sectioned for better representation of the water accessible channel

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Cell Communication and Signaling

ISSN: 1478-811X