Fig. 1

Examples of substrate preference logos (left) and anti-logos (right) for selected protein kinases. A PKACα (protein kinase cAMP-activated catalytic subunit alpha; gene symbol: Prkaca), B CDC2 (cyclin dependent kinase 1; gene symbol: Cdk1) coupled with Cyclin B1, C CK2a1 (casein kinase 2 alpha 1; gene symbol: Csnk2a1), and D EGFR (epidermal growth factor receptor, gene symbol: Egfr). Logos were generated in PTM-Logo using a Chi squared filtering α of 0.0001. Source: https://esbl.nhlbi.nih.gov/Databases/Kinase_Logos/). The colors of individual amino acids indicate different side chain properties: blue, basic; red, acidic; green, hydrophobic; black, aromatic; magenta, polar/uncharged; orange, no side chain