Skip to main content
Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Interplay between proteasome inhibitors and NF-κB pathway in leukemia and lymphoma: a comprehensive review on challenges ahead of proteasome inhibitors

Fig. 3

Autophagy’s dual-edge effect on NF-KB and PI resistance. In a physiological context, autophagy can impede the progression of malignancies by eliminating accumulated oncoproteins and inducing autophagic cell death. NF-KB, on the other hand, is primarily activated through canonical and non-canonical pathways, promoting cell survival during cellular stress conditions. PIs have the ability to hinder both of these NF-KB activating pathways, leading to apoptosis induction. However, various mechanisms that stimulate autophagy can give rise to resistance against PIs and cell death by degrading IKK-B and activating NF-KB

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X