Table 4 Effects of adipose-derived mesenchymal stem cell-derived exosomes on bone
From: Non-bone-derived exosomes: a new perspective on regulators of bone homeostasis
Cell Source | Exosome Cargo | Cargo Function | Role in Bone Metabolism | Reference |
|---|---|---|---|---|
AMSC | – | Promotes the expression of Bcl-2 and inhibits the expression of Bax. | Inhibits osteocyte apoptosis and osteoclastogenesis. | [136] |
AMSC | – | – | Attenuate TNF-α-induced osteoblast apoptosis. | [137] |
AMSC | – | Suppress NLRP3 inflammasome activation in osteoclasts | Reduce bone resorption. | [138] |
AMSC | miR-451a | Reduce the expression of MIF. | Promote macrophage M1-to-M2 polarization. | [140] |
AMSC | miR-130a-3p | Inhibit the expression of SIRT7 and increase the expression of proteins related to Wnt signaling pathway. | Promote osteogenic differentiation of ADSCs | [141] |
AMSC | – | Inhibit the expression of Nrf2. | Attenuates apoptosis in Dex-induced GIOP model and alleviates GIOP development. | [142] |
AMSC | – | Activate the Wnt/β-catenin signaling pathway to enhances the osteogenic potential of BMSCs. | Enhance the ability of bone repair and regeneration in vivo, promote fracture healing. | [143] |