Table 3 Different oncolytic viruses’ immunotherapy for CRC

Bispecific Engager Viruses

CEACAM5

Decreasing metastasis of CRC cells

[55]

Pseudorabies virus

HCT-8

Suppressed tumor proliferation both in vitro and in vivo

[56]

PexaVec

PD-1/CTLA-4

mismatch repair proficient (pMMR) metastatic CRC

[57]

Adenovirus H101

PD-1

promotes intratumor T-cell infiltration

[58]

Human adenovirus type 5

CRC specific Ag

Decreases patient complications and improves the patient’s quality of life

[59]

VAX014

Ki67

Decreased Ki67 proliferation

[60]

HSV-1

-

Increased IL-12 and CXCL-11

[61]