Table 3 Studies related to the role of exhausted NK cells in ALL
From: The role of exhausted natural killer cells in the immunopathogenesis and treatment of leukemia
Main findings | Ref |
|---|---|
The characterization of NK cells can predict ALL patients' clinical outcomes | [85] |
The activity of NK cells in ALL patients was significantly impaired compared to normal subjects | [86] |
B-ALL and T-ALL might differentially regulate NK cell exhaustion | [87] |
Molecular CRTAM/Necl-2 interaction in bone marrow niches leads to NK cell exhaustion | [88] |
Expansion of CD56−PD-1+ NK cells indicates chronic activation of NK cells in dasatinib-treated patients who were cytomegalovirus‐seropositive Combination therapy by blockade of PD-1/PD-L1 axis and dasatinib was suggested as a potential treatment approach for leukemia | [89] |
microRNA582 inhibits the cytotoxic effects of NK cells on leukemic cells by inducing the CD276 (B7-H3) checkpoint in ALL patients | [90] |
The expression of the OX40L checkpoint on NK cells and its interaction with OX40 on ALL cells causes the activation of NK cells and depletion of Leukemic cells in ALL patients | [91] |
Treating the 70Z/3 murine pre-B cell leukemia model by injecting IL-15-secreting leukemic cells induces and activates NK1.1+ cells, accompanied by increased mouse survival time | [92] |