Intratumoral microorganisms in tumors of the digestive system

Xuan, Mengjuan; Gu, Xinyu; Liu, Yingru; Yang, Li; Li, Yi; Huang, Di; Li, Juan; Xue, Chen

doi:10.1186/s12964-023-01425-5

Cell Communication and Signaling

Table 2 Regulatory effect of typical intratumoral bacteria on digestive system tumors

From: Intratumoral microorganisms in tumors of the digestive system

Bacterium	Regulator	Signaling pathway	Target	Regulation	Expression/Activity	Effect	Neoplasm promotion/suppression	Refs
Bacteroides fragilis	BFT	/	Interleukin-17	Positive	↑	DNA damage	promotion	[68]
	BFT	/	Spermine oxidase	Positive	↑	DNA damage	promotion	[120]
	BFT	β-catenin	E-cadherin	Negative	↓	tumor cell proliferation	promotion	[121]
	BFT	β-catenin	E-cadherin	Negative	↓	inducing c-myc expression	promotion	[122]
	BFT	NF-κB	ERK1/2, p38, and JNK kinases	Positive	↑	inducing intestinal inflammation and mucosal damage	promotion	[123]
	BFT	NF-κB	IκB	Negative	↓	inducing neutrophil migration	promotion	[124]
	BFT	NF-κB	Interleukin − 8	Positive	↑	inducing intestinal inflammation	promotion	[125]
	BFT	MAPK	human beta-defensin-2	Positive	↑	suppressing intestinal inflammation	suppression	[126]
	butyrate	nod-like receptor signaling pathway	Interleukin − 18 and Interleukin − 1β	Negative	↓	suppressing intestinal inflammation	suppression	[127]
	PSA	TLR-2	Interleukin − 10	Positive	↑	suppressing intestinal inflammation	suppression	[128]
	PSA	Interleukin − 12/Stat4	Th1	Positive	↑	inducing Th1 cytokine production	suppression	[129]
Escherichia coli	colibactin	/	Interleukin-17	Positive	↑	DNA damage	promotion	[68]
	colibactin	/	adenine	Negative	↓	DNA damage	promotion	[130,131,132,133]
	colibactin	/	copper	Positive	↑	DNA damage	promotion	[134]
	T3SS	/	UshA	Positive	↑	DNA damage	promotion	[135]
	VirF	/	PV-1	Positive	↑	gut vascular barrier damage	promotion	[34]
	acetic acid	/	Interleukin-1β, Interleukin-6, Interleukin-8, TNF-α	negative	↓	suppressing intestinal inflammation	suppression	[136]
	/	PI3K-AKT	PTEN	Negative	↓	inducing apoptosis	suppression	[137]
Fusobacterium nucleatum	/	TLR4	microRNA-21	Positive	↑	increasing tumor proliferation	promotion	[138]
	/	TLR4	12,13-EpOME	Positive	↑	promoting EMT and metastasis	promotion	[139]
	FadA	β-catenin	E-cadherin	Positive	↑	inducing intestinal inflammation	promotion	[140]
	/	NF-κB	PTGS2, Interleukin-1β, Interleukin-6, Interleukin-8, TNF-α	Positive	↑	inducing intestinal inflammation	promotion	[37]
	/	/	CCL20	Positive	↑	increasing tumor invasion	promotion	[48]
	/	/	CD3 + T	Negative	↓	suppressing antitumor immune response	promotion	[141]
	Fap2	/	TIGIT	Positive	↑	inhibiting NK cell cytotoxicity	promotion	[142]
	Fap2	/	CEACAM1	Positive	↑	inhibiting NK cell cytotoxicity	promotion	[143]
Helicobacter pylori	CagA	β-catenin	/	/	/	increasing β-catenin nuclear accumulation	promotion	[144]
	CagA	β-catenin	PPARδ	Positive	↑	inducing tumor proliferation	promotion	[145]
	CagA	NF-κB	Interleukin-8	Positive	↑	inducing intestinal inflammation	promotion	[146]
	/	/	N-acetyltransferase-10	Positive	↑	increasing mRNA acetylation	promotion	[147]
Salmonella typhi	AvrA	β-catenin	phosphorylated-β-catenin	Positive	↑	increasing nuclear accumulation of β-catenin	promotion	[148,149,150]

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ISSN: 1478-811X

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