Fig. 8From: IL13Rα2 as a crucial receptor for Chi3l1 in osteoclast differentiation and bone resorption through the MAPK/AKT pathwayReceptor and Molecular Mechanisms of Chi3l1 in Osteoclastogenesis. Chi3l1 interacts with IL13Rα2 on the bone marrow-derived macrophages (BMMs) membrane, acting as osteoclast precursors. This interaction promotes the activation of the RANKL-induced MAPK and AKT signaling pathways, eventually leading to osteoclast differentiationBack to article page