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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: IL13Rα2 as a crucial receptor for Chi3l1 in osteoclast differentiation and bone resorption through the MAPK/AKT pathway

Fig. 5

IL13Rα2 silencing suppresses the RANKL-induced activation of MAPK/AKT pathway. A After silencing IL13Rα2 expression in BMMs with IL13Rα2 siRNA for 48 h, BMMs were exposed to RANKL for 0, 10, 20, 30, and 60 mins. Then the phosphorylation of signaling pathways was analyzed by western blot. B Quantitative densitometric analysis was performed to normalize p-AKT, p-ERK, p-P38, p-JNK, and p-P65 expressions as shown in (A). **P < 0.01. Results are presented as means ± SD

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Cell Communication and Signaling

ISSN: 1478-811X