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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: IL13Rα2 as a crucial receptor for Chi3l1 in osteoclast differentiation and bone resorption through the MAPK/AKT pathway

Fig. 3

Increased binding of Chi3l1 to IL13Rα2 during early osteoclastic differentiation. M-CSF and RANKL were applied to induce osteoclastic differentiation of BMMs for 0, 1, 3, and 5 days. A, B The mRNA levels of Chi3l1 and IL13Rα2 during osteoclastogenesis. C The protein expressions of Chi3l1 and IL13Rα2 during osteoclastogenesis. D The culture supernatant concentration of Chi3l1 during osteoclastogenesis. E The location of Chi3l1 and IL13Rα2 in BMMs during osteoclast differentiation, as detected by immunofluorescence (IF) co-staining. F The binding of Chi3l1 and IL13Rα2 in BMMs, as confirmed by co-immunoprecipitation (IP), was increased after 24 hours of RANKL stimulation, w **P < 0.01. Results are presented as means ± SD

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Cell Communication and Signaling

ISSN: 1478-811X