Fig. 3
Target genes of Nrf2 involved in preventing ferroptosis. Nrf2 regulates ferroptosis mainly from three aspects: iron metabolism, lipid metabolism and intermediate metabolism. Many of the molecules involved in ferroptosis are target genes for Nrf2, which translocates to the nucleus and activates transcription of a number of antioxidant-related genes when cells are subjected to oxidative stress. GSTP1, glutathione S-transferase P1; GSTA1, glutathione S-transferase alpha 1; BLVRA, biliverdin reductase A; FECH, ferrochelatase; ALDH1A1, aldehyde dehydrogenase 1 family member A1; G6PD, glucose-6-phosphate dehydrogenase; AKR1B1, aldo-keto reductase family 1 member B1; AKR1B10, aldo-keto reductase family 1 member B10; SHP, small heterodimer partner; PPARG, peroxisome proliferator activated receptor gamma; NQO1, NAD(P)H quinone oxidoreductase 1