Table 2 The roles and mechanisms of the JAK–STAT pathway in digestive tract tumors
Human Diseases | Regulatory Mechanism of JAK-STAT pathway | Roles of the activated JAK-STAT pathway in cancers | Refs |
|---|---|---|---|
Liver cancer | CXCL6, JAK-STAT3 pathway, and SAA | tumor promoter | [136] |
Liver cancer | EYA2, DACH1, SOCS3, JAK2-STAT3 pathway | tumor promoter | [169] |
Liver cancer | GH, and STAT5 | tumor suppressor | [149] |
Liver cancer | GNMT, and JAK-STAT3 pathway | tumor promoter | [168] |
Liver cancer | TGFβ1, JAK-STAT3 pathway, and Twist | tumor promoter | [157] |
Liver cancer | leptin, JAK-STAT3 pathway, PI3K-AKT pathway, ERK signaling | tumor promoter | [156] |
Liver cancer | Hepatitis B virus, miR-340-5p, and JAK-STAT3 pathway | tumor promoter | [158] |
Liver cancer | sodium butyrate, JAK-STAT1 pathway, and IFN-α | tumor suppressor | [162] |
Liver cancer | SHP-1, and JAK-STAT3 pathway | tumor promoter | [170] |
Liver cancer | JAK-STAT3 pathway, AKT pathway, and β-catenin pathway | tumor promoter | [171] |
Gastric cancer | JAK-STAT3 pathway, and TLR2 | tumor promoter | [177] |
Gastric cancer | TFF1, and IL6-JAK-STAT3 pathway | tumor promoter | [181] |
Gastric cancer | G-CSF, JAK‐STAT3 pathway, and PD‐L2 | tumor promoter | [194] |
Gastric cancer | GM-CSF, JAK-STAT3 pathway, and PD-L1 | tumor promoter | [195] |
Gastric cancer | NF-κB1, JAK-STAT1 pathway, and PD-L1 | tumor promoter | [200] |
Gastric cancer | NF-κB1, JAK-STAT1 pathway, TNF, and PD-L1 | tumor promoter | [201] |
Gastric cancer | CXCL8, CXCR1/2, JAK-STAT1 pathway, and IL-10 | tumor promoter | [185] |
Gastric cancer | YTHDF1, IFNGR1, and JAK1/2-STAT1 pathway | tumor promoter | [190] |
Gastric cancer | STING, IL-6R-JAK-STAT1 pathway, and IL-24 | tumor promoter | [186] |
Colorectal cancer | BMX, HCK, and the JAK-STAT3 pathway | tumor promoter | [212] |
Colorectal cancer | circSPARC, miR-485-3p, and JAK2-STAT3 pathway | tumor promoter | [36] |
Colorectal cancer | IL-6-JAK-STAT3 pathway | tumor promoter | [211] |
Colorectal cancer | lncRNA FEZF1-AS1, PKM2, and JAK-TAT3 pathway | tumor promoter | [213] |
Colorectal cancer | JAK-STAT3 pathway, miR-572, MOAP-1 | tumor promoter | [217] |
Colorectal cancer | NF-κB, JAK-STAT3 pathway, miR-18a, and PIAS3 | tumor promoter | [218] |
Pancreatic cancer | TEAD2, CD109, and JAK-STAT3 pathway | tumor promoter | [223] |
Pancreatic cancer | KRAS, JAK-STAT3 pathway, YAP1, and TAZ | tumor promoter | [227] |
Pancreatic cancer | IL-22, JAK-STAT3 pathway, and TWIST | tumor promoter | [228] |
Pancreatic cancer | IFN-β, PPAR-γ, and JAK-STAT3 pathway | tumor promoter | [235] |
Esophageal cancer | JAK-STAT3 pathway, and PLK1 | tumor promoter | [244] |
Esophageal cancer | RNF168, and JAK-STAT1 pathway | tumor promoter | [246] |
Esophageal cancer | SNHG6, JAK-STAT3 pathway, and EZH2 | tumor promoter | [247] |
Esophageal cancer | EGFR, JAK1/2-STAT1/3 pathway, and MMP-1 | tumor promoter | [245] |