Fig. 4From: 14–3-3ε: a protein with complex physiology function but promising therapeutic potential in cancer14–3-3ε competitively binds to Gli to inhibit the Hedgehog signaling pathway. PKA promotes the interaction of Gli with 14–3-3ε, inhibits Gli translocation to the nucleus, and ultimately suppresses transcription of downstream genes. Gli, glioma-associated oncogene homolog 1; PKA, protein kinase ABack to article page