Fig. 2
From: 14–3-3ε: a protein with complex physiology function but promising therapeutic potential in cancer
14–3-3ε regulates cell proliferation through the Wnt/β-catenin and PI3K pathways. 14–3-3ε inhibits PI3K relocalization to the plasma membrane and thus inhibits PI3K/AKT/β-catenin signaling. Chibby, 14–3-3ε, and β-catenin in the nucleus form a complex that leads to β-catenin entry into the cytoplasm, which antagonizes β-catenin signaling. Meanwhile, 14–3-3ε promotes cell proliferation by inhibiting p27kip1 expression