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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: 14–3-3ε: a protein with complex physiology function but promising therapeutic potential in cancer

Fig. 1

Roles of 14–3-3ε in TGFβ-mediated signaling. 14–3-3ε enhances the TGFβ signaling pathway in two ways. First, 14–3-3ε interacts with TβRI to enhance the TGFβ signaling pathway. Second, co-expression of 14–3-3ε with EIF2α counteracts the inhibitory effect of EIF2α on TGFβ-mediated signaling. TGF, tumor growth factor; TβRI, type I TGFβ receptor; EIF2α, eukaryotic initiation factor-2α

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Cell Communication and Signaling

ISSN: 1478-811X