Table 2 Functions of oncogenes modified by ac4C in cancers
From: Recent advances in the potential role of RNA N4-acetylcytidine in cancer progression
Type | Factor | Tumor | Pathway | Targets | expression | Functions | References |
|---|---|---|---|---|---|---|---|
Writer | NAT10 | Colon cancer | NAT10-FSP1-ferroptosis signaling | FSP1 | overexpression | proliferation, metastasis | [55] |
Cervical cancer | NAT10-ac4C-HNRNPUL1 axis | HNRNPUL1 | overexpression | tumorigenicity, migration, invasion | [56] | ||
Gastric cancer | the Hp-NAT10-MDM2-p53 axis | MDM2 | overexpression | proliferation | [57] | ||
COL5A1 | overexpression | metastasis, EMT | [58] | ||||
Pancreatic cancer | LINC00623/NAT10 signaling axis | MUC4、LAMB3、PHGDH | overexpression | tumorigenicity, migration | [59] | ||
TGF-β pathway | TGF-β | overexpression | metastasis | [60] | |||
PI3K-AKT pathway | AKT | overexpression | proliferation | [60] | |||
Bladder cancer | BCL9L | overexpression | invasion, metastasis, proliferation | [33] | |||
SOX4 | overexpression | invasion, metastasis, prognosis | [33] | ||||
AKT1 | overexpression | invasion | [33] | ||||
Esophageal cancer | the NAT10-ac4C-tRNA-EGFR oncogenic axis | EGFR | overexpression | tumorigenicity | [61] | ||
CTC-490G23.2 | overexpression | invasion, metastasis | [62] | ||||
Hepatocellular carcinoma | COL15A1 | overexpression | prognosis | [63] | |||
G6PD、TP53I3 | overexpression | prognosis | [63] | ||||
Triple receptor-negative breast cancer | SNHG14 (H3K27) | overexpression | trastuzumab resistance | [64] | |||
GHSROS | overexpression | proliferation, migration | [64] | ||||
NONHSAT101069 | overexpression | epirubicin resistance , migration, invasion | [64] | ||||
RP11-22 N19.2 | overexpression | prognosis | [64] | ||||
USP8, COL3A1, TRIR | overexpression | prognosis | [64] | ||||
Reader | Unknown | ||||||
Eraser | Unknown |