Fig. 2

Succinate accumulation of peritoneal fluid from EMs patients is associated with clinical relevance. A Level of succinate in peritoneal fluid from EMs patients with different stages. Succinate was assessed via targeting organic acid metabolomics analysis (EMs I-II stage, n = 12; III-IV stage, n = 24) (Student’s t-test). B ROC curve for the assessment of EMs severity probability in cohort. C-E The Pearson correlation coefficient was used for clinical correlation, and result showed the level of succinate was positively correlated with pain grade VAS (R2 = 0.0.46, P < 0.001, 95% confidence interval is 0.15–0.68) and rAFS stage (R2 = 0.38, P < 0.02, 95% confidence interval is 0.06–0.63), negative with EFI. ***P < 0.001. VAS: Visual Analogue Scale; rAFS: revised American Fertility Society Scoring; EFI: endometriosis fertility index