Fig. 4
miR-320a is associated with worse prognosis and activation of the omental microenvironment. a Representative images of in situ hybridization for miR-320a and immunohistochemistry for α-SMA staining of ovarian cancer. Scale bar, 50 μm. b Survival curve of ovarian cancer patients with high and low expression of miR-320a in our hospital. c Survival curve of overall survival for ovarian cancer patients with high and low miR-320a expression in the GSE73581 dataset. d Curve of time to relapse for ovarian cancer patients with high and low miR-320a expression in the GSE73581 dataset. e The expression of miR-320a in stage I/II and stage III/IV ovarian cancer patients in the GSE73581 dataset. f Correlation between tumoral miR-320a expression and omental miR-320a expression. g Correlation between tumoral miR-320a expression and omental α-SMA levels. h Expression of miR-320a between intratumoral and extratumoral mesenchymal components in the metastatic omentum of ovarian cancer patients. i Expression of miR-320a in ascites-derived sEV (sEVascites) of ovarian cancer patients with and without omental metastases detected by RT–qPCR. * P < 0.05, ** P < 0.01, *** P < 0.001.