KIT mutations and expression: current knowledge and new insights for overcoming IM resistance in GIST

Table 2 Non-coding RNA associated with c-KIT

ncRNA	Cell lines	Mechanism of action	Function	Ref
miR-218	H1975, A549, GIST882, GIST48, GIST-T1, GIST430	Targeting IL-6/STAT3 signaling pathway, Targeting PI3K/AKT signaling pathway	Suppress	[122,123,124,125]
miR-148b-3p	GIST882	Directly binding to the 3’-UTR of the KIT mRNA	Suppress	[48, 126]
miR-221/222	TF-1, HL60, GIST882, GIST48, GIST-T1	Targeting KIT/AKT signaling pathway Directly binding to the 3’-UTR of the KIT mRNA	Suppress	[47, 127,128,129]
miR-142-5p	GIST882, GIST-T1			[131]
miR-9				[132]
miR-370
miR-501
miR-494	GIST430, GIST882	Downregulate surviving (BIRC5)	Suppress	[133]
miR17-92	GIST882, GIST-T1	Directly binding to the 3’-UTR of the KIT mRNA Downregulate ETV1	Suppress	[134]
miR-20a	GIST882, GIST-T1		Suppress	[134]
miR-375-3p	GIST-T1	Directly binding to the 3’-UTR of the KIT mRNA Downregulate ETV1		[135]
miR-200b-3p	GIST-T1			[135]
CCDC26	HL60, GIST882, GIST-T1		Suppress	[137,138,139]
H19				[141]
FENDRR				[141]

ISSN: 1478-811X