Table 1 KIT mutation and its activated downstream in GIST cell lines
Cell lines | KIT mutations | Mutation downstream | TKI resistance and IC50 (nM) IM SU RE | Ref |
|---|---|---|---|---|
GIST-T1+ | Exon 11: V570-Y578 (Hom) | MAPK pathway PI3K pathway Wnt pathway Notch pathway STAT3 | S S S 16.54 15.00 110.00 | |
GIST-882+ | Exon 13: K642E (Hom) | MAPK pathway PI3K pathway STAT3 | R S R 173.00 54.00 503.00 | |
GIST-48+ | Exon 11: V560D (Hom) Exon 17: D820A (Het) | MAPK pathway PI3K pathway JAK/STAT pathway | R R R 413.00 587.00 164.00 | |
GIST-430+ | Exon 11: (V560-L576) (Het) Exon 13: V654A (Het) | MAPK pathway PI3K pathway | R R R 61.00 68.00 191.00 | |
GIST-BOE+ | Exon 9: A502_Y503dup | MAPK pathway | R NR NR NR | |
GIST-PSW+ | Exon 11: K558_G565delinsR | MAPK pathway | S NR NR NR | |
HG129+ | Exon 11: 45 bp insertion between F591- 592G | MAPK pathway | S NR NR 42.00 NR NR | [55] |
GIST-522− | Exon 11: delEVQWK554-558 (het) | NR | R NR NR NR | [49] |
GIST-62− | Exon 11: MYEVQWK552-558T (het) | NR | R NR NR NR | [49] |
GIST-226− | Exon 11: P551-W557 (Hom) Exon 17: Y823D (Hom) | MAPK pathway | R R R  > 5000.00 3856.00 > 5000.00 | |
GIST-48B− | Exon 11: V560D (Hom) Exon 17: D820A (Het) | MAPK pathway | R R R  > 5000.00 > 5000.00 > 5000.00 | |
GIST-5− | Exon 11 | NR | NR NR | [58] |
GIST-474− | Exon 11 | NR | NR NR | [58] |
HG209− | Exon 11: delYIDPTQL 570–576 Exon 17: D816H | MAPK pathway | R R NR  > 1000.00 NR NR | [59] |
GIST-544− | Exon9: AY503-504ins (Het) | MAPK pathway STAT1 and STAT3 | NR NR | [60] |