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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Chemoproteomics-based profiling reveals potential antimalarial mechanism of Celastrol by disrupting spermidine and protein synthesis

Fig. 2

Identification of Cel potential antimalarial targets in P. falciparum based on the ABPP strategy. A The structure of Cel and Cel-P. B The antimalarial activity of Cel and Cel-P against P. falciparum 3D7 strain. C The workflow of ABPP for the profiling of Cel target proteins. D In situ fluorescence labeling of Cel-P in parasite proteins. E In situ competition experiment of Cel-P by Cel. F Confocal imaging showed the distribution of Cel-P in parasites with or without excess Cel (scale bar = 1 μm). G Heatmap representation of the target proteins identified by the Cel-P. H Gene ontology (GO) enrichment analysis for all potential targets of Cel-P. CBB, Coomassie brilliant blue; RBC, red blood cells; HZ, hemozoin; TAMRA, carboxy tetramethyl rhodamine

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Cell Communication and Signaling

ISSN: 1478-811X