Fig. 1

Celastrol shows potential antimalarial effects in vivo in PbANKA infected C57BL/6 mice. A The scheme of animal modeling and drug handling. C57BL/6 mice were divided into five groups (Control; model; ATS treatment; Cel treatment; ATS + Cel treatment). B Daily parasitemia was monitored by Giemsa staining. C-D The behavioral observations and body temperature measurements on the first day and last day. E The histopathological observations of liver and spleen using H&E staining (scale bar = 50 μm). F-G The organ index of liver and spleen in each group after treatment. H-I The levels of serum ALT and AST in each group after treatment. All data were presented as mean ± standard error of the mean (SEM), ^###P < 0.001 vs control; ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 vs model. ATS, artesunate; Cel, Celastrol