Skip to main content
Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Paxillin participates in the sphingosylphosphorylcholine-induced abnormal contraction of vascular smooth muscle by regulating Rho-kinase activation

Fig. 7

A schematic diagram showing that paxillin participates in the SPC-induced vascular smooth muscle contraction mediated by the Fyn/paxillin/Rho-kinase pathway. When stimuli factor SPC acts on vascular smooth muscle cells, Fyn is activated and translocated to the focal adhesion to bind to paxillin, resulting in Rho-kinase activation, which increases actin stress fiber formation and phosphorylation of MLC, triggering vascular smooth muscle abnormal contraction (vasospasm)

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X