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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Paxillin participates in the sphingosylphosphorylcholine-induced abnormal contraction of vascular smooth muscle by regulating Rho-kinase activation

Fig. 6

Paxillin knockdown inhibits SPC-induced actin stress fiber formation and myosin light chain phosphorylation. a, Immunofluorescence staining of the SPC-induced actin stress fiber formation in control and paxillin knockdown human CASMCs. Scale bar = 20 µm. b, Statistical analysis of the SPC-induced actin stress fiber formation in control and paxillin knockdown human CASMCs. Data were obtained from three independent experiments, and at least 44 cells were counted. c and d, Western blot showing the myosin light chain (MLC) phosphorylation in paxillin knockdown human CASMCs (c) and paxillin SMKO mice (d). e and f, Statistical analysis of MLC phosphorylation in paxillin knockdown human CASMCs (e, n = 4) and paxillin SMKO mice (f, n = 4). *p<0.05; **p<0.01. Cont: control mice; PXN KO: paxillin SMKO mice

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Cell Communication and Signaling

ISSN: 1478-811X